ISS National Lab Launches Orbital Edge Accelerator Program to Support Startups

Insider Brief

• The ISS National Lab has launched the Orbital Edge Accelerator to support space-based innovation, offering six startups up to $500,000 each, mentorship, and access to ISS-sponsored research missions in low Earth orbit.
• Backed by investors CIRI, E2MC, and Stellar Ventures, and supported by TechConnect and AWS, the program targets early-stage companies developing technologies in sectors like advanced materials, biotech, and communications.
• Applications are due May 19, 2025, with finalists pitching virtually; selected startups will be announced at the ISS R&D Conference in Seattle, July 28–31, 2025.

PRESS RELEASE – The International Space Station (ISS) National Laboratory is taking a giant leap in fostering new space innovators with the launch of the Orbital Edge Accelerator program. This bold initiative is designed to integrate cutting-edge startups and investment partners into the rapidly expanding space economy. Through the accelerator, six pioneering startups will be selected to receive an investment of up to $500,000 each—which is being provided by global investors Cook Inlet Region, Inc. (CIRI), E2MC, and Stellar Ventures—along with mentorship and the opportunity to launch an ISS National Lab-sponsored investigation. By bridging the gap between early-stage companies and space-based innovation, the Orbital Edge Accelerator program aims to unlock discoveries that can benefit humanity and drive new commercial opportunities in low Earth orbit(Abbreviation: LEO) The orbit around the Earth that extends up to an altitude of 2,000 km (1,200 miles) from Earth’s surface. The International Space Station’s orbit is in LEO, at an altitude of approximately 250 miles..

Engaging the startup community is a strategic priority for the ISS National Lab. Having access to the unique space environment allows entrepreneurs to push the boundaries of science and technology, develop novel products, and build new businesses. Over the years, dozens of startups have been awarded flight opportunities through the ISS National Lab to advance R&D in diverse areas, from communications and remote sensing to advanced materials and biotechnology. The impact of conducting research through the ISS National Lab is notable, as startups awarded flight projects have cumulatively raised nearly $2.4 billion in funding postflight, demonstrating the value of space-based R&D in accelerating commercialization. With the launch of the Orbital Edge Accelerator, the ISS National Lab aims to build on this momentum and fuel the next wave of innovators that will shape the future space economy.

To deliver the accelerator program, the ISS National Lab is working with TechConnect, which has more than 25 years of expertise connecting innovators with high-value commercialization opportunities. In the coming months, representatives from the ISS National Lab, CIRI, E2MC, Stellar Ventures, and TechConnect will meet with interested startups at conferences and networking sessions to highlight the accelerator and discuss how space-based R&D can lead to innovation not possible on Earth. Additionally, AWS will serve as a corporate partner for the Orbital Edge Accelerator program, providing their extensive expertise and reach toward scouting and mentoring the inaugural cohort of startups. 

TechConnect will host an informational webinar on April 22, 2025, at 2:00 p.m. EDT providing additional details on the scope of this opportunity and the advantages of utilizing the orbiting laboratory. To register, please visit the webinar registration page. TechConnect will also host two office hours for potential respondents to ask questions about the accelerator program. Learn more about these opportunities on the accelerator webpage.

Startups interested in the Orbital Edge Accelerator program will need to submit an application by 8:00 p.m. EDT on May 19, 2025. Once the application window closes, the ISS National Lab and investment partners will evaluate each submission and select up to 20 finalists to pitch in a virtual setting. From there, reviewers will invite six startups to join the Orbital Edge Accelerator cohort. Each startup will receive a $500,000 investment and the opportunity to submit an official proposal to utilize the ISS National Lab in a future spaceflight mission.

The six selected startups will be joining attendees at the 14^th annual ISS Research and Development Conference in Seattle July 28-31, 2025. To learn more about the accelerator program, networking events, and application process, visit the Orbital Edge Accelerator webpage.